By Timo Jäger, Oliver Koch, Leopold Flohé
This can be the 1st source to supply researchers in academia and with an urgently wanted replace on drug intervention opposed to trypanosomatides. As such, it
covers each element of the subject from uncomplicated study findings, through present remedies to translational techniques in drug improvement and comprises either human and farm animals illnesses. the phenomenal editor and contributor group reads like a Who?s Who of the sector, hence making certain the exceptional caliber of this prepared reference.
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Additional info for Trypanosomatid Diseases: Molecular Routes to Drug Discovery
2007) Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat. Rev. , 5, 873–882. , and Alvar, J. (2010) Of cattle, sand ﬂies and men: a systematic review of risk factor analyses for South Asian visceral leishmaniasis and implications for elimination. PLoS Negl. Trop. , 4, e599. , and Kinuthia, J. (2010) Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial. PLoS Negl. Trop. , 4, e709.
This is observed in 75–90% of the animals treated. However, parasitological cure of the dogs is not achieved and relapses are the rule in about 75% of the cases 6–8 months posttreatment [40–42]. As observed in human leishmaniasis, the presence of resistant strains of L. infantum to meglumine antimoniate in dogs has sporadically been reported [40,43]; this resistance development could be related to inappropriate under-dosage of the drug. As mentioned, treatment schedules in canine leishmaniasis are variable and this holds also true for meglumine antimoniate dosing.
Opin. Infect. , 23, 595–602. , and Boelaert, M. (2010) Combination therapy for visceral leishmaniasis. Lancet Infect. , 10, 184–194. N. (1993) Epidemic visceral leishmaniasis in Sudan: a randomized trial of aminosidine plus sodium stibogluconate versus sodium stibogluconate alone. J. Infect. , 168, 715–720. B. (1992) Treatment of visceral leishmaniasis (kalaazar) with aminosidine (¼ paromomycin)– antimonial combinations, a pilot study in Bihar, India. Trans. R. Soc. Trop. Med. , 86, 615–616. D.
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