By The International Agency for Research on Cancer
Evaluates or re-evaluates the carcinogenic dangers to people posed through publicity to 16 natural commercial chemical compounds. those integrated a few fragrant amines (ortho-toluidine, 4-chloro-ortho-toluidine, and 5-chloro-ortho-toluidine), a few ethanolamines (di- and triethanolamine and N-nitrosodiethanolamine), and 3 esters [di(2-ethylhexyl) phthalate (DEHP), di(2-ethylhexyl) adipate, and cinnamyl anthranilate]. Seven of the 16 compounds have been evaluated in prior IARC Monographs and are reconsidered the following within the gentle of latest evidence.Three chemical substances have been categorised or reclassified as most likely carcinogenic to people: ortho-toluidine, 4-chloro-ortho-toluidine, and glycidol. 4 compounds, evaluated the following for the 1st time, specifically 2,2-bis(bromomethyl)propane-1,3-diol, 2,3-dibromopropan-1-ol, ethylbenzene, and nitromethane, have been labeled as very likely carcinogenic to people. N-Nitrosodiethanolamine, which could conveniently be shaped from both di- or triethanolamine within the presence of inorganic nitrite, remained categorized as in all probability carcinogenic to humans.For 8 compounds, together with 5-chloro-ortho-toluidine, coumarin, pyridine, diethanolamine, triethanolamine, di(2-ethylhexyl) adipate, and cinnamyl anthranilate, proof used to be judged insufficient to categorise those compounds based on their carcinogenicity in people. the main broad monograph is dedicated to an overview of di(2-ethylhexyl) phthalate (DEHP), which had formerly been labeled as very likely carcinogenic to people. utilizing evaluation standards lately validated for compounds that result in peroxisome proliferation within the liver, the evaluate downgraded DEHP to the gang of compounds that can not be categorised. different compounds that reason peroxisome proliferation, di(2-ethylhexyl) adipate and cinnamyl anthranilate, have been additionally evaluated as now not classifiable as to carcinogenicity to people.
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Extra info for Some Industrial Chemicals Volume 77 (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans)
78/003) IARC (1978–1993) Environmental Carcinogens. Methods of Analysis and Exposure Measurement, Lyon, IARCPress Vol. 1. Analysis of Volatile Nitrosamines in Food (IARC Scientific Publications No. 18). Edited by R. Preussmann, M. A. E. Wasserman (1978) Vol. 2. Methods for the Measurement of Vinyl Chloride in Poly(vinyl chloride), Air, Water and Foodstuffs (IARC Scientific Publications No. 22). M. Squirrell & W. Thain (1978) Vol. 3. Analysis of Polycyclic Aromatic Hydrocarbons in Environmental Samples (IARC Scientific Publications No.
In the past, nitrites were occasionally added to soluble oils. N-Nitrosodiethanolamine has been detected in some bulk samples of soluble oils (National Institute for Occupational Safety and Health, 1998). By the 1950s, water-soluble fluids were being increasingly used in high-production operations. Semi-synthetic fluids contain smaller amounts of oil than soluble oils (3–30%), along with the same mixture of additives mentioned below for synthetic fluids. They are typically diluted 1:10 to 1:40 for use.
5 mg/kg dry matter (Wams, 1987). , 1978). (d) Foods The most common route of human exposure to di(2-ethylhexyl) phthalate is through food contamination. 3 mg/day per individual, with a maximum exposure of 2 mg/day (WHO, 1992; Agency for Toxic Substances and Disease Registry, 1993). , 1990; Petersen, 1991; WHO, 1992; Agency for Toxic Substances and Disease Registry, 1993; Gilbert, 1994). , 1994). The highest levels of di(2-ethylhexyl) phthalate have been measured in milk products, meat and fish as well as in other products which have a high fat content.
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