By Mark Evans
A complete reference on analysis and evaluate of reproductive hazards and genetically similar high-risk pregnancies. Authored by way of foreign team of specialists, this booklet is prepared in line with diagnostic technique, resource of reproductive danger, and process less than evaluate. positive factors the newest imaging expertise, a evaluation of genetics, molecular biology, and cytogenetics, and distinctive chapters on counseling, cross-cultural, criminal, and moral concerns. (20060804)
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Extra info for Prenatal Diagnosis
The prevalence of the disorder in Down syndrome is difﬁcult to determine as there are no standardized criteria for dementia in individuals with mental disability. 5 State-wide information systems were used to investigate 2,534 affected individuals and over 16,000 controls with other forms of mental disability. Dementia was deﬁned in terms of declining adaptive behavior. No excess in dementia was seen until age 50. 3 at 61–70. In the oldest group the prevalence of dementia was 50% using the most lenient criteria and 15% for the most severe.
Genetics & Reproductive Risks The unusual and puzzling characteristics of inheritance of the fragile X syndrome arise from a “dynamic” mutation: the ampliﬁcation of a repetitive sequence of 3 nucleotides (cytosine-guanine-guanine). 3 contains between 2–60 copies of CGG. An increase in the number of CGG repeats to 60–200 copies is known as a premutation characteristic of normal transmitting males and some normal carrier females. A premutation is signiﬁcant because, when passed to offspring, it may develop into a full mutation (many hundreds to thousands of CGG repeats).
2. Tjio HJ, Levan A. The chromosome number of man. Hereditas. 1956;42:1. 3. Down JLH. Observations of an ethnic classiﬁcation of idiots. Clinical Lecture Reports, London Hospital 1866;3:259. 4. Lejeune J, Gauthier M, Turpin R. Etude des chromosomes somatiques de neuf enfants mongoliens. Cr Acad Sci Paris. 1959;248: 1721. 5. Smith HO, Wilcox KW. A restriction enzyme from Hemophilus Inﬂuenza; I. Puriﬁcation and general properties. J Mol Biol. 1970; 51:393. 6. Kelly TJ Jr, Smith HO. A restriction enzyme from Hemophilus Inﬂuenza; II.
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