By Luana Colloca, Magne Arve Flaten, Karin Meissner
The placebo impression keeps to fascinate scientists, students, and clinicians, leading to a magnificent quantity of analysis, regularly within the box of soreness. whereas contemporary experimental and scientific reviews have unraveled salient elements of the neurobiological substrates and medical relevance of discomfort and placebo analgesia, an authoritative resource remained missing before. by means of offering and integrating a extensive diversity of study, Placebo and Pain complements readers' wisdom approximately placebo and nocebo results, reexamines the technique of medical trials, and improves the healing ways for sufferers struggling with pain.
Review for Placebo and Pain: ''This bold e-book is the 1st complete and unified presentation of the placebo and nocebo phenomena within the sector of discomfort. Written by way of the foreign top specialists within the box, the ebook offers a correct up to date [work] on placebo and ache facing present views and destiny not easy issues.”--Ted Kaptchuk, affiliate Professor of drugs, Harvard clinical School
- Contains old features of the placebo effect
- Discusses organic and mental mechanisms of placebo analgesic responses
- Reviews implications of the placebo impact for scientific learn and ache management
- Includes methodological and moral elements of the placebo effect
Read or Download Placebo and Pain. From Bench to Bedside PDF
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Additional info for Placebo and Pain. From Bench to Bedside
1999;103(2):203-209. Day HE, Badiani A, Uslaner JM, et al. Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala. J Neurosci. 2001;21(2):732-740. Uslaner J, Badiani A, Day HE, et al. Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens. Brain Res. 2001;920(1–2):106-116. de la Fuente-Fernandez R, Phillips AG, Zamburlini M, et al.
If replicated in clinical samples, these trait measures could be employed to reduce variability in treatment trials for conditions, such as persistent pain, mood and movement disorders, where placebo effects can be particularly prominent and obscure the effects of potentially active treatments. CONCLUSIONS An emerging literature is demonstrating that cognitive and emotional processes that are engaged during the administration of an otherwise inactive agent, a placebo, are capable of activating internal mechanisms that modify physiology.
It was sively localized in mesolimbic dopaminergic terminal hypothesized that in healthy subjects, in the absence of fields, ventral caudate, ventral putamen and NAC. underlying pathology or previous conditioning, indiThe magnitude of DA activation in the NAC was posi- vidual variations in placebo-induced NAC DA activity, tively correlated with the individual verbally-induced and in the synaptic activity of this region during reward MOLECULAR MECHANISMS OF PLACEBO RESPONSES IN HUMANS anticipation, would be related to each other and to the variability in placebo effects obtained in the studies.
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