Download Parkinson Disease: A Health Policy Perspective by Egon Jonsson(eds.) PDF

By Egon Jonsson(eds.)

A part of the winning Institute of health and wellbeing Economics (IHE) booklet sequence, this guide and prepared reference adopts a distinct procedure in combining coverage techniques with particular treatment plans for Parkinson patients.
the 1st a part of the publication offers with the medical scientific, social and low cost features of Parkinson affliction. those ten chapters contain the newest prognosis and remedies for sufferers, the low-budget outcomes, social and moral implications and end-of existence concerns. the second one a part of the ebook primarily covers a large-scale case examine on Parkinson in Alberta, Canada, due to the fact that many of the matters mentioned are proper in all built countries.
With its robust specialise in right analysis and early intervention, this can be a useful consultant for clinicians and policymakers facing this devastating affliction.

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Extra resources for Parkinson Disease: A Health Policy Perspective

Sample text

5 Dopamine Agonists Dopamine agonists directly stimulate the dopamine receptors, with bromocriptine (Parlodel®) and pergolide (Permax®) having been available in Canada for the treatment of PD for many years. More recently, two newer dopamine agonists – ropinirole (Requip®) and pramipexole (Mirapex®) – have become available. These differ from the older compounds in that they are not ergot derivatives, and are therefore devoid of ergot-related side effects such as retroperitoneal or pleural fibrosis.

3 Catechol-O-Methyl Transferase (COMT) Inhibitors Levodopa is metabolized peripherally not only by decarboxylase (as described above) but also by COMT. The latter is a ubiquitous enzyme, and is sufficiently active that when levodopa is administered with a peripheral decarboxylase inhibitor, only about 10% of a given dose will reach the brain intact [15]. Entacapone (Comtan®) inhibits the peripheral metabolism of levodopa by COMT, thereby increasing its availability to the brain, and increasing the plasma levodopa elimination half-life by about 50% [16].

Although these movements are typically twisting or writhing, dystonic features (characterized by sustained muscle contraction leading to abnormal limb postures) may also be present in some affected individuals. Dyskinesias most often appear in a peak-dose pattern, evident during periods of otherwise good motor function. These movements appear to be related to an excessive stimulation of dopamine receptors, but they can also occur during “off ” periods. “Off ” dyskinesias are typically dystonic, and seem to be related to an inadequate activation of dopamine receptors.

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