Download New Natural Products and Plant Drugs with Pharmacological, by N. R. Farnsworth, A. S. Bingel (auth.), Prof. Dr. H. Wagner, PDF

By N. R. Farnsworth, A. S. Bingel (auth.), Prof. Dr. H. Wagner, Dr. P. Wolff (eds.)

The incontrovertible fact that, of the nearly 600,000 plant species current on this planet, just some five % were in particular investigated chemically or pharmacologi­ cally, is a problem to chemists spezializing in na­ tural components and to pharmacologists. In view of the constrained variety of study capacities and the ever­ diminishing monetary potential, this problem can simply be met if, including an development and refinement of tools of research, medicinal plant examine is conducted on a broader interdisciplinary foundation, with similar, scientifically well-known screening equipment, and whether it is larger coordinated, with larger use of contemporary documentation skill. it really is therefore priceless sooner or later to pay attention particularly on initiatives resulting in the improvement of latest medicinal prepara­ tions. The plenary lectures carry within the current symposium of the first foreign Congress for study on Medi­ cinal vegetation mirror those efforts and traits. even as they supply a survey of a few of the fields of medicinal plant study that are at this time so much real and such a lot intensively researched. they vary from plant screening, isolation and constitution eluci­ dation of recent rules, to the therapeutical opti­ mization of a common product. The lectures given at this congress convey truly the need, as well as nationwide phytochemical so­ cieties, for a important overseas organization, during which all energetic medicinal plant researchers on this planet are integrated. Their goal could be to supply the impulse for extra optimum, rational examine, aimed toward the answer of particular projects.

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Additional resources for New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity: Proceedings of the First International Congress on Medicinal Plant Research, Section A, held at the University of Munich, Germany, September 6–10, 1976

Sample text

Biological and phytochemical evaluation of plants. XIV. Antiinflammatory evaluation of 163 species of plants. Lloydia 39, 260-271 (1976) 9. : Biological and phytochemical evaluation of plants. I. Biological test procedures and results from two hundred accessions. Lloydia 29, 101-122 (1966) 10. : Anomalous isolation of an active antitumor alkaloid from a fraction of Catharanthus Lanaeus devoid of antitumor activity. J. Pharm. Sci. 21, 1840-1841 (1972) 11. : Antifertility agents. Ann. Rev. Pharmacol.

36 Both the mouse (Irwin, 1964) and rat (Malone and Robichaud, 1962) screens are observational and require a standardized worksheet. Both require technicians trained-on-the-job to be consistent in rating the drug-induced symptomatology. Neither demands expensive equipment to perform. Only the rat screen requires that all blanks on the work-sheet must be filled in to be sure that some parameter has not been inadvertently overlooked. This requirement (although merely one of procedure) is important in that the absence of symptomatology is virtually as important as the presence of symptomatology in evaluating the data.

The original worksheet of Malone and Robichaud (1962) was modified to conform to the restricted working hours of the company, and further altered so as to be compatible with punch-card data storage and retrieval methods. Failure to perform on a rotarod and effects on blood glucose levels were added as new parameters for measurements. The resultant two-page form is illustrated in Figure 3 (front) and Figure 4 (back). g. note the effects on pupil diameter). The goals for the computerized hippocratic screen were to provide a rapid data retrieval system and a rapid and unbiased in-depth comparison of each test sUbstance against a "library" of similarly tested prototype drugs with known clinical utility.

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