Download Neuroglia in the Aging Brain (Contemporary Neuroscience) by Jean S. de Vellis PDF

By Jean S. de Vellis

A distinct panel of across the world famous neuroscientists comprehensively overview the involvement of and adjustments in glial cells either through the general getting older strategy and within the significant issues of outdated age. themes variety from the mobile and molecular adjustments that ensue with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal damage and repair-to neuron-glia intercommunication. The members express how glial signs could be modulated by way of hormones, progress components, neurotransmitters, intracellular metabolism, and intercellular exchanges, in addition to via getting older of the blood-brain barrier.

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H. (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20, 570–577. 5. -L. and Privat, A. K. ) Vol. 6 (in press). Jai Press Inc. Stamford, CT, USA. 6. G. H. ) Edward Arnold Ltd. London, pp. 1–66. 7. F. S. (1994) GFAP and astrogliosis. Brain Pathol. 4, 229–237. 8. A. (1979) Normal and reactive astrocytes: a comparative study by immunohistochemistry and by a classical histological technique. Cell Molec. Biol. 24, 237–239. 9. , and Brotchi, J. (1981) Four types of reactive astrocytes.

Totowa, NJ 35 36 Boya et al. species, VIM-GFAP transition takes place in the first weeks of life after birth, as a result of which GFAP and VIM may be temporarily coexpressed by most astrocytes during such transition periods (7–11). Moreover, biochemical studies have revealed changes in the presence of messenger RNA (mRNA) encoding for both GFAP and VIM during this period (12). Once development has been completed, astrocytes express variable amounts of GFAP. Whereas the concentration of the latter is high in fibrous astrocytes of the white matter (13), it may be very low in certain regions of the brain cortex—where protoplasmic astrocytes (at least in the rat) cannot be detected by the habitual immunohistochemical techniques (14)—with the exception of layer I astrocytes that form the glia limitans, which are clearly GFAP-positive.

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