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By Guy K. Macintire

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Neuropathic pain is a kind of pathological pain due to a dysfunction of or damage to the nervous system. Peripheral neuropathic pain means pain due to a dysfunction of or damage to 20 Li Li and Xin-Fu Zhou a nerve or group of nerves, primarily peripheral nociceptor afferents (Millan, 1999). Etiologically, it has different types, such as traumatic, metabolic, infectious, toxic, ischaemic, hereditary, compression by tumor and immune-mediated neuropathies (Figure 2). Syndromes of neuropathic pain comprise a complex combination of positive and negative symptoms.

1996). The actions of LTB4 are mediated via its chemotactic action on neutrophils. , 1998a). 4. Effects of NGF on Central Sensitization NGF has been implicated in the spinal processing of nociceptive information. The peripheral action of NGF on the activation and sensitization of primary afferent nociceptors may trigger central changes in the spinal cord. , 1995) to peripheral targets has been shown to increase spinal neuron excitability to inputs from unmyelinated afferents. Peripheral NGF administration to some visceral tissues results in the induction of c-fos in dorsal horn (Dmitriva, 1996).

1993), one of plasticity changes occurs in the neuropathic pain models. , 1994). , 1993). , 1999), conversely the administration of NGF antiserum prevents sympathetic sprouting into the DRG in the CCI model (Ramer and Bisby, 1999). , 1996). , 1999). , 1997). In addition to sympathetic sprouting, mast cells also plays important role in mediating the indirect action of NGF on peripheral sensitization. , 1993). Mast cells release inflammatory mediators such as histamine and serotonin known to excite and sensitize primary afferent nociceptors.

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