Download Multiple Sclerosis As A Neuronal Disease by Stephen Waxman PDF

By Stephen Waxman

This booklet examines the function of neurons in a number of sclerosis (MS) and the adjustments that happen in neurons due to MS. It areas MS in a brand new and demanding viewpoint that not just explains the foundation for symptom construction, remission, and growth in MS, but in addition grants to open up new healing probabilities. * Brings jointly the newest details from medical, pathological, imaging, molecular, and pharmacological geographical regions to discover the neurobiology of a number of Sclerosis* areas MS in a brand new and critical point of view that provides to open up new healing avenues* beautifully illustrated and referenced

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Hallin, R. , and Norén, G. (1995). Return of function after spinal cord implantation of avulsed spinal nerve roots. Lancet 346, 1323–1325. Clifford-Jones, R. , Landon, D. , and McDonald, W. I. (1980). Remyelination during optic nerve compression. J. Neurol. Sci. 46, 239–243. Cooper, M. , and Beal, J. A. (1977). Myelinated granule cell bodies in the cerebellum of the monkey (Saimiri sciureus). Anat. Rec. 187, 249–256. , and Carlstedt, T. (1989). Marchi-positive myelinoid bodies at the transition between the central and the peripheral nervous system in some vertebrates.

65–82. Raven Press, New York. , and Llena, J. F. (1995). Morphology of central nervous system axons. In “The Axon” (S. G. Waxman, J. D. Kocsis, and P. K. ), pp. 49–67. Oxford University Press, Oxford and New York. Hirokawa, N. (1982). Cross-linker system between neurofilaments, microtubules and membranous organelles in frog axons revealed by the quickfreeze deep-etching method. J. Cell Biol. 94, 129–142. , Glicksman, M. , and Willard, M. B. (1984). Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton.

How these and other factors influencing developmental pathways leading to myelination are coordinated with axon maturation is poorly understood. , 1996). Dialogues: Communication Between Axons and Myelinating Glia Early developmental interactions with axons are required for survival and further differentiation of OL progenitors. , 1999). Detailed descriptions of OL development are outside the scope of this chapter. Instead, we will try to place the expression of these stimulation and repression factors in the framework of the developing axon-glial cell contacts that occur throughout the various stages of myelination.

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