Download Models of seizures and epilepsy by Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé MD PDF

By Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé MD

An figuring out of mechanisms underlying seizure issues relies seriously at the insights supplied via version platforms. specifically with the advance of mobile, molecular, and genetic investigative instruments, there was an explosion of simple epilepsy examine. Models of Seizures and Epilepsy brings jointly, for the 1st time in 30 years, an outline of the main widely-used types of seizures and epilepsy.

Chapters disguise a large diversity of experimental methods (from in vitro to complete animal preparations), quite a few epileptiform phenomenology (including burst discharges and seizures), and recommendations for version characterization and validation, resembling electrographic, morphologic, pharmacologic, and behavioral gains. specialists within the box supply not just technical reports of those versions but additionally conceptual reviews - commenting at the strengths and boundaries of those types, their dating to scientific phenomenology, and their price in constructing a greater realizing and treatments.

Models of Seizures and Epilepsy is a precious, sensible reference for investigators who're trying to find the main acceptable laboratory versions for addressing key questions within the box. It additionally offers a major historical past for physicians, fellows, and scholars, delivering perception into the potential of advances in epilepsy research.

  • The first finished description of animal versions of epilepsy because the early 1970's
  • Comprehensive research of "What the types version" to steer the choice of every version, and what particular questions it's going to answer
  • Elegant examples of using novel applied sciences that may be utilized in experimental epilepsy research
  • World professional reviews at the scientific relevance of every model

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Sample text

1986). Given such a starting point, the acutely dissociated cell preparation is ideal for the study of pacemaker properties—that is, those intrinsic neuronal properties that lead to a burst firing pattern—of neurons in a generator region. , 2001; Stewart and Wong, 1993), which have endogenous burst firing properties and recurrent connections. We have compared properties of acutely dissociated CA1 pyramidal cells in hippocampus with subicular pyramidal cells (Figure 1) and found that the acutely dissociated subicular cells generate a pattern of inward currents (when the cells are stimulated with depolarizing current) that is consistent with action potential burst generation.

These examples are meant to illustrate the preparation “in action” and to suggest other possible applications. Endogenous Bursting and Pacemaker Cells Characterization of Receptor Properties As much as the acutely dissociated cell cannot, by definition, be used as a model to study seizures per se (abnormal neuronal synchronization—involving multiple neurons—is an essential component of the definition of a seizure), the preparation can be used to study abnormalities in cellular properties that contribute to seizure generation.

J Physiol 509(Pt 1): 39–45. K. 1984. Voltage-clamp study on GABA response desensitization in single pyramidal cells dissociated from the hippocampus of adult guinea pigs. Neurosci Lett 47(3): 289–294. A. 1995. Postnatal development of GABAA receptor function in somatosensory thalamus and cortex: whole-cell voltage-clamp recordings in acutely isolated rat neurons. J Neurosci 15(2): 1341–1351. O. 1990. Influences of trypsin and collagenase on acetylcholine responses of physically isolated single neurons of Aplysia californica.

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