By Challa S. S. R. Kumar
Explores the newest purposes bobbing up from the intersection of nanotechnology and microfluidics
In the previous 20 years, microfluidics learn has visible extraordinary progress, with many new and rising purposes in fields starting from chemistry, physics, and biology to engineering. With the emergence of nanotechnology, microfluidics is at present present process dramatic adjustments, embracing the emerging box of nanofluidics.
This quantity reports the most recent units and functions stemming from the merging of nanotechnology with microfludics in such components as drug discovery, bio-sensing, catalysis, electrophoresis, enzymatic reactions, and nanomaterial synthesis. all the ten chapters is written by way of a number one pioneer on the intersection of nanotechnology and microfluidics. Readers not just know about new functions, but in addition observe which futuristic units and purposes usually are built. subject matters explored during this quantity include:
New lab-on-a-chip structures for drug delivery
Integration of microfluidics with nanoneuroscience to check the frightened method on the single-cell level
Recent purposes of nanoparticles inside microfluidic channels for electrochemical and optical affinity biosensing
Novel microfluidic ways for the synthesis of nanomaterials
Next-generation substitute power moveable energy devices
References in every one bankruptcy advisor readers to the first literature for additional research of person themes. total, scientists, researchers, engineers, and scholars won't basically achieve a brand new viewpoint on what has been performed, but additionally the nanotechnology instruments they should improve the following new release of microfluidic units and applications.
Microfluidic units for Nanotechnology is a two-volume e-book, the 1st ever to discover the synergies among microfluidics and nanotechnology. the 1st quantity covers basic recommendations; this moment quantity examines applications.
Read Online or Download Microfluidic Devices in Nanotechnology: Applications PDF
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Extra info for Microfluidic Devices in Nanotechnology: Applications
B) Fluorescence micrograph of a portion of the myotube microarray after staining the AChRs with Alexa Fluor 488-conjugated a-bungarotoxin (BTXÃ ). Scale bar is 50 mm. (c) Three high-magnification fluorescence micrographs of myotubes stained with BTXÃ , showing that aneural AChR clusters display intricate shapes similar to those found in vivo. (d) Phase contrast micrograph of the microfluidic device containing a ladder micropattern of myotubes during stimulation by a laminar stream of agrin (spiked with Allura red dye for visualization).
B) Scanning electron micrograph of three recording capillary orifices as seen from the main chamber. The capillary dimensions are 4 mm Â 3 mm, with a site-to-site distance of 20 mm. (c) Dark-field optical microscope image of cells trapped at three capillary orifices. Trapping was achieved by applying negative pressure to the recording capillaries. The device consists of 12 capillaries arrayed 6 along each side of the main chamber fluidic channel along a 120 mm distance. Reprinted with permission from Ref.
148 They used PDMS microchannels to guide single pheochromocytoma PC12 cells into a chamber etched into glass. When this cell was stimulated with nicotine, they could detect dopamine release by amperometric monitoring using a carbon fiber microelectrode. 151 They recorded amperometric spikes using indium tin oxide (ITO) electrodes when the catecholamines were oxidized on the electrode surface. When trying to differentiate the complex interactions that occur between different cells in mixed-type or pure-type cultures, it is important to determine the cell’s chemical response to stimulation, in addition to its electrical and morphological responses.
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