By Alejandra Carvajal-Cuenca MD, Stefano A. Pileri MD, PhD, Elias Campo MD, PhD (auth.), Anas Younes, Bertrand Coiffier (eds.)
Recently, knowing the molecular pathogenesis of malignant lymphomas has ended in development within the diagnostic precision and to the identity of various molecular healing ambitions. additionally, new medicines were licensed within the US and Europe, leading to alterations within the typical of care of different types of lymphoid malignancies. complete in scope and constructed via a crew of across the world popular authors, Lymphoma: prognosis and Treatment presents a well timed replace at the most crucial advances within the biology, prognosis, and treatment of lymphomas. As a part of the present medical Oncology sequence, Lymphoma: analysis and Treatment can be of price to clinical oncologists, hematologists, radiation oncologists, and all physicians interested by the care of sufferers with lymphoid malignancies.
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Additional resources for Lymphoma: Diagnosis and Treatment
2007;7:750–62. 31. Mozos A, Royo C, Hartmann E, et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica. 2009;94:1555–62. 32. Carvajal-Cuenca A, Sua LF, Silva NM, et al. In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior. Haematologica. 2012;97:270–8. 33. Roullet MR, Martinez D, Ma L, et al. Coexisting follicular and mantle cell lymphoma with each having an in situ component: a novel, curious, and complex consultation case of coincidental, composite, colonizing lymphoma.
Four histological subtypes are distinguished based on the characteristics of the inflammatory background: lymphocyte rich (LRCHL), nodular sclerosis (NSCHL), mixed cellularity (MCCHL), and lymphocyte depleted (LDCHL). These histological subtypes of HRSC have identical immunophenotypic and genetic features, whereas clinical features and EBV association may be different. , the lacunar cell. CHL represents 95 % of all HLs, presenting a bimodal age curve in resource-rich countries, with a peak at 15–35 years of age and a second peak late in life.
A) Diffuse infiltration of medium cells with a starry-sky pattern due to the abundant macrophages with apoptotic bodies (H&E, ×200). (b) Monotonous neoplastic infiltrate composed of medium-sized cells with high proliferation (H&E, ×400) or a non-IG-gene partner, and complex karyotypes are common. A strong expression of BCL-2 protein should suggest the presence of a t(14;18) in addition to a t(8;14) (“double hit”) . Borderline cases are not considered a specific entity but a working category, because further studies are needed for their precise recognition and clinical management.
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