By Stanley T. Crooke
Lipoxygenases are enzymes concerned with the conversion of arichidonic acid to leukotrienes and lipoxins. those serve quite a few vital features and feature been implicated in a variety of human ailments. This e-book seems on the constitution, pharmacology, and mobile mechanisms of motion of lipoxygenases and their metabolic items.
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Austen, K. , and Lewis, R. A. (1983). Immunologie and ionophore-induced generation of leukotriene B4 from mouse bone marrow-derived mast cells. J. Immunol. 130, 1885-1890. , Hill, R. , Watkins, W. , Petkau, A. , and Zapol, W. M. (1983). Effects of leukotrienes B4 and C4 on coronary circulation and myocardial contractility. Surgery 94, 267-275. 1. Pharmacology and Pathophysiology of 5-Lipoxygenase Products 45 142. , Hill, R. , Watkins, W. , Petkau, A. , and Zapol, W. M. (1982). Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction.
Petkau, A. , and Zapol, W. M. (1983). Effects of leukotrienes B4 and C4 on coronary circulation and myocardial contractility. Surgery 94, 267-275. 1. Pharmacology and Pathophysiology of 5-Lipoxygenase Products 45 142. , Hill, R. , Watkins, W. , Petkau, A. , and Zapol, W. M. (1982). Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. Science 217, 841-843. 143. , and Shida, T. (1986). Effect of AA-861, a 5-lipoxygenase inhib itor, on leukotriene synthesis in human polymorphonuclear leukocytes and on cyclooxygenase and 12-lipoxygenase activities in human platelets.
Leitch, A. , and Drazen, J. M. (1984). Pulmonary mechanical response to leuko triene administration in vivo. In "Asthma Physiology Immunopharmacology and Treatment" Third Int. Symposium. Academic Press, Orlando. Letts, L. G. and Piper, P. J. (1982). The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts. Br. J. Pharmacol. 76, 169-176. , Austen, K. , and Corey, E. J. (1981). Functional characterization of synthetic leukotriene B4 and its stereochemical iso mers. J. Exp. Med. 154, 1243-1248.
