Download Lead-Seeking Approaches by Kevin D. Freeman-Cook, Daniel W. Kung (auth.), Matthew M. PDF

By Kevin D. Freeman-Cook, Daniel W. Kung (auth.), Matthew M. Hayward (eds.)

Christopher A. Lipinski: evaluate of Hit to guide: The Medicinal Chemist’s position from HTS Retest to guide Optimization Hand Off

Jeff W. Paslay • John E. Morin • Richard ok. Harrison: excessive Throughput Screening within the Twenty - First Century

Jack Andrew Bikker • Lakshmi S.Narasimhan: Lead Discovery utilizing digital Screening

Maurizio Pellecchia: NMR Spectroscopy in Fragment dependent Drug Design

Kevin D. Freeman-Cook • Daniel W. Kung: Hit Triage – Medicinal Chemistry thoughts to enhance the chances of luck in Discovery

John W. Ellingboe • Adam M. Gilbert: Lead Identification

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3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. Gladwell M (2005) Blink: the power of thinking without thinking. 1007/7355_2009_6 # Springer‐Verlag Berlin Heidelberg 2009 Published online: 23 July 2009 High Throughput Screening in the Twenty-First Century Jeff W. Paslay, John E. Morin, and Richard K. Harrison Abstract High throughput screening (HTS) has become the cornerstone of lead identification for small molecules in drug discovery during the last quarter century.

Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 27 27 27 31 37 49 54 54 55 59 59 60 61 61 64 66 69 71 72 72 81 1 Introduction Discovering a drug and completing the subsequent phases of clinical development is hard.

7 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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