Download IL27 by Kastelein R.A., Pflan S. PDF

By Kastelein R.A., Pflan S.

Interleukin 27 (IL-27) is a heterodimeric cytokine that includes a 4 helix package cytokine-like subunit, termed p28, and a soluble cytokine receptor-like subunit, EBI3 (Epstein-Barr virus-induced gene 3). The p28 subunit has homology with different single-chain cytokines, while EBI3 is expounded to the extracellular area of the hematopoietic cytokine receptor kinfolk. As such, IL-27 is a member of a small kin of heterodimeric cytokines that incorporates IL-12 and IL-23. effective expression and secretion of the IL-27 heterodimer calls for coexpression of p28 and EBI3. either subunits are produced by means of activated antigen-presenting cells (APCs) and the presence of either is needed for the biologic task of IL-27. mobile ambitions comprise naive CD4+ T cells and NK cells (Pflanz et aL, 2002). The hematopoietic cytokine receptor WSX-1/TCCR, including a minimum of one extra - but to be pointed out - receptor subunit(s) is thought to mediate the biologic task of IL-27.

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IL27

Interleukin 27 (IL-27) is a heterodimeric cytokine that includes a 4 helix package cytokine-like subunit, termed p28, and a soluble cytokine receptor-like subunit, EBI3 (Epstein-Barr virus-induced gene 3). The p28 subunit has homology with different single-chain cytokines, while EBI3 is said to the extracellular area of the hematopoietic cytokine receptor family members.

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