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By Max R. Bennett

An try and supply a background of these discoveries about the id and serve as of synapses that offer the rules for examine in this new century.

summary: An try to offer a historical past of these discoveries in regards to the identity and serve as of synapses that offer the principles for study in this new century

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Extra resources for History of the synapse

Example text

A, Purkinje cell stained with osmic acid; B, basket cell, a, b, pericellular axonal ramifications forming baskets; C, axon (from Cajal, 1995). (B) The endings of cerebellar basket cells in a cat (twenty-five days old) twenty-four hours after axotomy of the Purkinje cells, which destroy them. A, almost normal Purkinje cell; B, Purkinje cell undergoing atrophy and granular in appearance; D, baskets surrounding the empty spaces previously occupied by Purkinje cells that are now destroyed (from Cajal, 1959).

Regarding how synapses operate, he said: It would be a mechanism where nervous conduction, especially if predominantly physical in nature, might have grafted upon its characters just such as those differentiating reflex-arc conduction from nerve-trunk conduction. Sherrington had developed these ideas as a consequence of his studies on the reflex contractions of muscles following stimulation of muscle and skin afferents. His summary diagram of the place of excitation and inhibition in reflex pathways for flexor activation and extensor inhibition, shown in Fig.

9D). The fact that these have ended up being approximately correct does not mean that Cajal should be credited for their discovery, which would be for profoundly wrong reasons, namely based on the conduction of action potentials by neurofibrils. It might be commented on in passing that Cajal’s work was not subject to review until towards the end of his life, as it was published privately. In summary then the neuron doctrine could not be considered to be definitively supported by this silver stain work.

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