Download Hepatology 2012: A Clinical Textbook by Stefan Mauss, Thomas Berg, Juergen Rockstroh, Christoph PDF

By Stefan Mauss, Thomas Berg, Juergen Rockstroh, Christoph Sarrazin, Heiner Wedemeyer

Hepatology is a swiftly constructing quarter of drugs. The interesting new oral remedies for HCV, breakthroughs within the therapy of continual hepatitis B, and the id of genes linked to metabolic liver illnesses are only a few highlights. Hepatology 2012 is an up to date resource of data for physicians, citizens and complex scientific scholars looking a broader realizing of liver disorder.

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Extra resources for Hepatology 2012: A Clinical Textbook

Sample text

There are considerable regional differences. , Egypt, the prevalence is as high as 22% (WHO 2011). In Africa and the western Pacific the prevalence is significantly higher than in North America and Europe (RKI 2004). It is estimated that there are 2-5 million HCV-positive persons in Europe. 23% in Scandinavia (RKI 2004, Hatzakis 2011). The number of patients HCV RNApositive is estimated to be around 80 to 90% of all HCV antibody-positive persons. Certain groups are preferentially affected: The highest risk factor in most cases is injection drug use.

They tend to decrease in most patients, although increases in transaminases and bilirubin have also been described. Reducing dosage of corticosteroids returns HCV viral load to baseline. However, the clinical consequences of corticosteroid use are largely unknown. It seems to be reasonable to assume that short-term use of corticosteroids is not associated with significant changes in long-term prognosis. Viral factors: The influence of viral factors on disease progression is unclear.

Exposure of HCV to intact skin has not been associated with HCV transmission. Clinical manifestations The spectrum of clinical manifestations of HCV infection varies in acute versus chronic disease. Acute infection with HCV is most often asymptomatic (Vogel 2009) and leads to chronic infection in about 80% of cases. The manifestations of chronic HCV range from an asymptomatic state to cirrhosis and hepatocellular carcinoma. HCV infection usually is slowly progressive. Thus, it may not result in clinically apparent liver disease in many patients if the infection is acquired later in life.

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