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Extra resources for Handbook of Neurochemistry and Molecular Neurobiology: Brain and Spinal Cord Trauma (Springer Reference)
Ho JK, Moser H, et al. 1995. Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy. J Clin Invest 96(3): 1455-1463. Holzinger A, Kammerer S, et al. 1997. cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter. Biochem Biophys Res Commun 239(1): 261-264. Igarashi M, Belchis D, et al. 1976. Brain gangliosides in adrenoleukodystrophy. J Neurochem 27(1): 327-328.
Although Lorenzo’s oil and statin treatments were reported to correct the metabolic defect in X-ALD fibroblasts in culture and plasma of X-ALD patients, it remains to be seen if such treatments will attenuate the neuroinflammatory and clinical disease of X-ALD patients. Ideally, any pharmacological intervention should include treatment for both the metabolic as well as the inflammatory disease. Acknowledgements We would like to thank Dr. Avtar K. Singh for helpful suggestions and for the revision of this manuscript.
1991. Fatty acid composition of human myelin proteolipid protein in peroxisomal disorders. J Neurochem 56(3): 872-878. Bourre JM, Paturneau‐Jouas MY, et al. 1977b. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl‐CoA‐dependent synthesis and microsomal malonyl‐CoA chain‐elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur J Biochem 72(1): 41-47. Bourre JM, Pollet S, et al. 1977b. Saturated and mono‐unsaturated fatty acid biosynthesis in brain: Relation to development in normal and dysmyelinating mutant mice.
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