Download Handbook of Nanoindentation: With Biological Applications by Michelle L. Oyen PDF

By Michelle L. Oyen

Nanoindentation is perfect for the characterization of inhomogeneous organic fabrics. even though, using nanoindentation innovations in organic platforms is linked to a few distinctively diversified recommendations and demanding situations. The booklet provides the fundamental technology of nanoindentation, together with the historical past of touch mechanics underlying indentation strategy and the instrumentation used to collect mechanical info. It presents views which are optimized for organic functions, together with discussions on hydrated fabrics and variations for low-stiffness fabrics. The ebook additionally covers the functions of nanoindentation procedure in organic fabrics. Highlighting present demanding situations, it concludes with an insightful forecast of the future.

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Contact Behavior Sensed by an Atomic Force Microscope Atomic force microscopy (AFM) typically operates at the other extreme of partitioning the imposed displacement of the probe between the contact and the spring. Similar to IIT, AFM enables the displacement of a probe to be measured along with the load during loading onto a test surface. However, in AFM the resistance of the tip to elastic and plastic deformation is not always much greater than that of the surface (often the tip and surface are the same material), and AFM, as the name implies, is often used to measure adhesive force behavior.

Extent of hydration Most biological material samples exist at superambient states of humidity and hydration. To the extent possible, the physiological degree of hydration, salinity, and overall ion content of the biological solutions surrounding the biomaterial in vivo should be recapitulated in experiments. This is because the structure of these materials is maintained by such hydration, and is responsible for the mechanical properties of the biomaterial. For biological materials such as soft tissues that are fully hydrated in vivo, it is optimal to conduct instrumented indentation experiments within a fluid cell that is filled with solution of appropriate ionic strength and pH.

Similar to an elements-in-series concept, the indentation modulus takes into account deformation in both the tip and the surface during contact and is given by 1 1 1 = + (2-9) M M tip M surface where Mtip and Msurface are the indentation moduli of the tip and surface, respectively. For elastically isotropic materials, the isotropic indentation Indentation and Adhesion at Small Length Scales 29 modulus, Miso, is related to the material Young’s modulus, E, and Poisson’s ratio, ν, by E M iso = , (2-10) 1− ν 2 which may be recognized as the isotropic “plane-strain” modulus.

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