By R. W. Wissler (auth.), Javad Hekmatpanah M. D. (eds.)
When i used to be requested by way of the melanoma instructing Committee of the collage of Chicago to establish a Symposium on mind Tumors, I welcomed the chance to take action. yet I felt that "Brain Tumors" used to be a long way too huge an issue to hide in an afternoon and a part assembly. additionally, in past times decade, there were a good many papers and symposiums on technical developments within the therapy of benign mind tumors. nevertheless, whereas gliomas make up someplace round 50% of all mind tumors, there have definitely been some distance fewer communications approximately them. for that reason i presumed that it'd be hugely precious to ask a few of the top investigators to percentage with us their event with gliomas. The desire used to be to benefit the present innovations approximately those tumors biologically and therapeutically, particularly to determine what we're doing and the place we're moving into those respects. obviously all features couldn't be lined. however, it was once a extensively expressed opinion by way of the audio system that they too realized whereas they got here to coach. it's as a result was hoping that the e-book in their works and ideas via this mono graph may also be worthy for the reader. many of the manu scripts have been passed in on the time of the Symposium, and some have been despatched later. apart from minor editorial alterations the phrases are solely these of the audio system and authors.
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Additional resources for Gliomas: Current Concepts in Biology, Diagnosis and Therapy
KOTSILIMBAS, D. , SCHEINBERG, L. : Evaluation of parenteral 5-FU on experimental brain tumors. &, 91 6 ( 1 966) . 8. KOTSILIMBAS, D. , TAYLOR, J. , SCHEINBERG, L. : Corticosteroid effect on intracerebral melanomata and associated cerebral edema: Some unexpected findings. Neurology 17, 223 (1967). 9. , DONELLI, M. : Chemotherapy of tumors transplanted intracerebrally. European J. Cancer 3, 125 (1967). 10. , YARBRO, J. : Effect of mithramycin on a mouse glioma. Cancer Res. 28, 91 (1968). 11. SHAPIRO, W.
In Neuropathology II, 335 (1973). 22. , WILSON, C. , NIELSEN, S. : Development of an animal brain tumor model and its response to therapy with 1, 3-Bis (2-chloroethyl)-1-nitrosurea. Cancer Res. 33, 976 (1973). 23. DAY, E. , BIGNER,-o. : Specificity, cross-reactivity, and affinity of 125I-labeled antiglioma antibodies for monolayers of cultured glioma cells. Cancer Res. 33, 2362 (1973). 24. : Personal communication. 25. BIGNER, D. : Unpublished results. 26. : Personal communication. 27. : Studies on the reproduction and cell-converting abilities of avian sarcoma viruses.
The paradoxical situation therefore exists in which a tumor presumed to have exhibited pro~ gressive anaplasia in vivo will reverse its cellular evolution along the pathway of differentiation when transferred to an in vitro system. This has long been known to be the case in glioblastoma. It was strikingly demonstrated in the case, already referred to, of cerebellar and brain stern glioma in which the concomitant picture of a diffusely infiltrating astrocytoma and focal medulloblastoma was present.
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