Download Gamma-hydroxybutyrate : molecular, functional, and clinical by Godfrey Tunnicliff, Christopher D. Cash PDF

By Godfrey Tunnicliff, Christopher D. Cash

Gamma-hydroxybutyrate (GHB) has come far when you consider that early experiments in animals the place it was once came upon to urge a sleep-like nation and from its use typically anaesthesia in human matters. it's been came upon to be a naturally-occurring compound within the mind, a metabolite of GABA, the rising ubiquitous inhibitory neurotransmitter. This has spread out a totally new line of study in order to determine a functionality for GHB.

Gamma-Hydroxybutyrate: Pharmacological and useful points has introduced jointly the mixed services of the various prime specialists at the biochemistry, body structure and pharmacology of GHB within the critical worried approach. each one bankruptcy is an in-depth assessment of the sector and the ebook itself will attract all neurobiologists drawn to neurotransmitter mechanisms, in addition to to clinicians and different health-care employees attracted to this interesting chemical.

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Extra resources for Gamma-hydroxybutyrate : molecular, functional, and clinical aspects

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R. H. (1972) Effect of gamma-hydroxybutyrate on dopamine and dopamine metabolites in the rat striatum. Biochem. Pharmacol. 21, 2111–21. P. E. (1956) Effects of fatty acid anions on electroencephalogram of unanesthetized rabbits. Am. J. Physiol . 186, 271–78. D. E. (1965) Various seizure activities following γhydroxybutyrate. Int. J. Neuropharmacol . 4, 197–200. Xie X. G. (1992) γ-Hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors. Eur. J. Pharmacol . 212, 291–94. , et al.

2). Although receptor homodimers had previously been described for GPCRs (Hébert and Bouvier 1998; Angers et al. 2000), GABAB receptors are the first clear evidence for heterodimerization among GPCRs. The GABAB receptor dimer appears to be the basic building block for most, if not all, GABAB receptors in the brain. In situ hybridization and light microscopic immunohistochemistry revealed their co-localization in agreement with the distribution of GABAB receptor binding sites previously identified by autoradiography (Bischoff et al.

2001; Duthey et al. 2002). A new class of compounds, the positive modulators, binds to the GABAB(2) subunit (Urwyler et al. 2001). These compounds do not activate the receptor on their own; rather they potentiate the efficacy and affinity of agonists on the GABAB receptor, as observed with the benzodiazepines on the GABAA receptor. GHB is not a positive modulator of the GABAB receptor. ) a member of family 3 G protein-coupled receptors (GPGRs). The two most prominent splice variants GABAB(la) and GABAB(lb) differ in their extreme amino-terminal Part of the pharmacological actions of γ-hydroxybutyrate 39 sequence, but share ligand-binding and effector domains.

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