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By Lee, Paul J.

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Purification of an antimicrobial peptide from rabbit aqueous humour, Curr Eye Res (1998) 17:783–7.  Expression of human beta­defensins in intraocular tissues, Invest Ophthalmol Vis Sci (2000) 41:3026–31.  Clinical Ophthalmic Pharmacology (Little Brown: Boston/Toronto, 1987) 173–92.  Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins, Invest Ophthalmol Vis Sci (2000) 41:3492–502.  Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59, Invest Ophthalmol Vis Sci (2000) 41:4195–202.

Intravitreal corticosteroids in the treatment of exogenous fungal endophthalmitis, Retina (1992) 12:46–51.  Intravitreal corticosteroids as an adjunct in the treatment of bacterial and fungal endophthalmitis: a review, Retina (1992) 12:340–66.  The blood­borne route must always be considered for endophthalmitis when there is no history of accidental or surgical trauma, particularly the possibility of endocarditis or a previous, possibly contaminated blood transfusion; intravenous drug abusers are also more likely to develop endophthalmitis, particularly with Candida albicans (Chapter 9).

Pneumoniae have been lysed.  Klebsiella pneumoniae also tests positive.  coli are prototype indole­positive organisms, Some bacteria are able to break down the amino acid tryptophan, releasing indole; its presence can be detected through the use of Kovacs’ reagent, which turns red.  Unchanging color indicates a negative test.  When urea is broken down and ammonia is released, the pH of the medium becomes more alkaline, causing the pH Indicator to turn pink. Other tests Automated identification systems are now widely used based on 10 or 23 differentiating media­impregnated well ‘strips’ (API) that cost approximately $1 each.

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