By Sanjeev Saksena MBBS MD FACC FESC FHRS FAHA, A. John Camm MD FRCP FESC FACC FAHA FHRS
The hot variation of Electrophysiological problems of the center is helping you diagnose and deal with an entire variety of middle rhythm problems utilizing cutting-edge most recent applied sciences and treatments. It presents functional, hands-on assurance of scorching subject matters similar to pediatric EP, imaging, echocardiography-guided EP techniques, regenerative cures, cardiac pacing, and extra. Now on hand in a brand new full-color layout, the name additionally comprises effortless on-line entry at www.expertconsult.com. observe new how you can deal with and deal with the total diversity of middle rhythm issues with content material fascinated about universal medical positive aspects, prognosis, and administration. overview specialist administration ideas that can assist you deal with advanced sufferer difficulties. remain present with the newest molecular and technical advances in addition to new treatments carried out over the past few years. Use the most recent applied sciences and units to thoroughly diagnose and deal with middle rhythm problems. seek advice new and extended insurance of regenerative treatments, echo-guided techniques, cardiac pacing, and CRT, in addition to a brand new part on pediatric electrophysiology and imaging. get pleasure from greater visible suggestions with many new full-color photos. go surfing to www.expertconsult.com to simply seek the whole contents on-line and entry a downloadable photo library. find out about and observe the most recent applied sciences and scientific & gadget treatments to regard electrophysiological problems.
Read or Download Electrophysiological Disorders of the Heart: Expert Consult - Online and Print, 2e PDF
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Extra info for Electrophysiological Disorders of the Heart: Expert Consult - Online and Print, 2e
Papke RL, Smith-Maxwell C: High throughput electrophysiology with Xenopus oocytes, Comb Chem High Throughput Screen 12(1):38–50, 2009. 40. Ly H, Kawase Y, Yoneyama R, et al: Gene therapy in the treatment of heart failure, Physiology (Bethesda) 22:81–96, 2007. 41. Lehrman S: Virus treatment questioned after gene therapy death, Nature 401:517–518, 1999. 42. Abbas-Terki T, Blanco-Bose W, Deglon N: Lentiviral-mediated RNA interference, Hum Gene Ther 13:2197–2201, 2002. 43. Tiscornia G, Singer O, Verma IM: Design and cloning of lentiviral vectors expressing small interfering RNAs, Nat Protoc 1(1):234–240, 2006.
After the AV node, the cardiac action potential propagates through the cardiac conduction system comprising the AV bundle (bundle of His), the left and right bundle branches, and the cardiac Purkinje system. 2 Importantly, Purkinje fibers communicate with the ventricular mass at welldefined discrete loci (Purkinje-muscle junctions). Form Fits Function: The Ventricular Cardiomyocyte and ExcitationContraction Coupling As is discussed in detail in Chapter 3, the electrical activity of cardiac cells (the action potential) is primarily modulated by the coordinated movement of sodium (Na+), calcium (Ca2+), and potassium (K+) across the external plasma membrane (sarcolemma) and the internal sarcoplasmic reticulum (SR) membrane.
1 Fr octapolar murine electrophysiology catheter. B, An octapolar electrode catheter was introduced via a right internal jugular vein approach. The catheter was positioned to situate the center electrodes at the tricuspid valve annulus to record atrial, His bundle, and ventricular local electrograms by bipolar configuration. Wild-type mice display normal surface electrocardiogram intervals and normal intracardiac atrial-His (AH) and His-ventricular (HV) intervals. In contrast, connexin40 null mice display PR prolongation on the surface electrocardiogram and prolonged AH and HV intervals.
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