By Michael T. Mazur M.D., Robert J. Kurman M.D. (auth.)
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Additional resources for Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach
20. Cervical contaminants. f4t. Fragrnentation has resulted in a strip ofmucinous glandular epithelium adjacent to detached proliferative phase glands. Right. Amorphous endocervical mucus with a few macrophages may be admixed with endometrial tissues. This finding has no significance. docervical glands with squamous metaplasia or microglandular hyperplasia yield complex patterns, but these elements are cytologically bland and usually blend into more typical cervical epithelium (Fig. 21). In questionable cases, continuity with endometrial surface epithelium may help to establish origin in the corpus.
IT cells and decidua. The IT cells (arrows) have irregular, hyperchromatic nuclei that contrast with the round to oval, uniform nuclei of the surrounding decidualized stroma! cells. 18. IT cells in myometrium. Curetted placental site from an abortion includes a fragment of myometrial smooth muscle infiltrated by large IT cells. These cells often become multinucleated when they invade the myometrium. 19. IT cells. Prominent infiltration ofblood vessels in the decidua by IT cells in an abortion specimen.
Other Glandular Changes in Pregnancy Besides the Arias-Stella reaction, the endometrial gland cells may undergo other specific changes in the presence of trophoblastic tissue. One such change is abundant clear cytoplasm. 16 This phenomenon overlaps with the Arias-Stella reaction yet does not show the nuclear enlargement of the latter. With this change the gland cells accumulate abundant amounts of clear, glycogen-rich cytoplasm (Fig. 9). 9. Gestational endometrium with clear cell change. Glands in early gestational endomtrium are lined by cells with abundant clear cytoplasm.
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