Download Cyclic-Nucleotide Phosphodiesterases in the Central Nervous by Nicholas J. Brandon, Anthony R. West PDF

By Nicholas J. Brandon, Anthony R. West

This publication stories advances in realizing phosphodiesterases in the critical apprehensive procedure and their therapeutic functions. a variety of specialist authors from either academia and describe those, then specialize in the parts of maximum clinical and clinical curiosity to supply extra precise assurance. healing and drug discovery functions are coated for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile disorder, and spinal twine accidents. there's additionally a bankruptcy on drug discovery instruments corresponding to in vitro assays and X-ray constructions for medicinal chemistry reviews.

Show description

Read Online or Download Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery PDF

Similar neuroscience books

The Human Brain Book

The Human mind publication is a whole consultant to the single organ within the physique that makes each one folks what we're - particular participants. It combines the most recent findings from the sphere of neuroscience with professional textual content and state of the art illustrations and imaging innovations to supply an incomparable perception into each aspect of the mind.

A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates

This atlas maps the certain architectonic subdivisions of the cortical and subcortical parts within the macaque monkey mind utilizing high-resolution magnetic resonance (MR) pictures and the corresponding histology sections within the similar animal. This publication provides the special mapping of the architectonic components within the horizontal airplane of sections just about the MRI that has no longer been suggested formerly in macaque monkeys.

Translational Neuroscience: Fundamental Approaches for Neurological Disorders

Translational Neuroscience bargains a far-reaching and insightful sequence of views at the attempt to convey possibly progressive new periods of cures to the health facility, thereby reworking the remedy of human fearful process issues. nice advances within the fields of uncomplicated neuroscience, molecular biology, genomics, gene remedy, cellphone treatment, stem cellphone biology, info expertise, neuro units, rehabilitation and others over the past two decades have generated remarkable possibilities to regard heretofore untreatable problems of the worried method.

Extra resources for Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery

Example text

85. , and Mengod, G. (2001) Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs. Synapse, 40:201–214. 86. , and Omori, K. (2002) Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation. Biochem. , 361:211–220. 87. E. 3: alternative splicing of mRNA transcripts, genomic structure and sequence. Hum. , 103:386–392. 88. D. (2007) Cellular functions of PDE4 enzymes. D. ), Cyclic Nucleotide Phosphodiesterases in Health and Disease, Boca Raton, FL: CRC Press, pp.

123. , and Koenig, G. (2004) Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology, 47:1081–1092. 124. U. M. (2002) Hydrolysis of N-methyl-D-aspartate receptorstimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus. J. Pharmacol. Exp. , 302:249–256. 125. Domek-Lopacinska, K. B. (2008) The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging.

2006) Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc. Natl. Acad. Sci. USA, 103:15124–15129. 118. , and De Vente, J. (2003) mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain. J. Comp. , 467:566–580. 34 PHOSPHODIESTERASES AND CYCLIC NUCLEOTIDE SIGNALING IN THE CNS 119. , and de Vente, J. (2004) Species differences in the localization of cGMP-producing and NOresponsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry.

Download PDF sample

Download Cyclic-Nucleotide Phosphodiesterases in the Central Nervous by Nicholas J. Brandon, Anthony R. West PDF
Rated 4.96 of 5 – based on 41 votes