By Nicholas J. Brandon, Anthony R. West
This publication stories advances in realizing phosphodiesterases in the critical apprehensive procedure and their therapeutic functions. a variety of specialist authors from either academia and describe those, then specialize in the parts of maximum clinical and clinical curiosity to supply extra precise assurance. healing and drug discovery functions are coated for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile disorder, and spinal twine accidents. there's additionally a bankruptcy on drug discovery instruments corresponding to in vitro assays and X-ray constructions for medicinal chemistry reviews.
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Extra resources for Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery
85. , and Mengod, G. (2001) Differential distribution of cAMP-speciﬁc phosphodiesterase 7A mRNA in rat brain and peripheral organs. Synapse, 40:201–214. 86. , and Omori, K. (2002) Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-speciﬁc expression and phosphorylation. Biochem. , 361:211–220. 87. E. 3: alternative splicing of mRNA transcripts, genomic structure and sequence. Hum. , 103:386–392. 88. D. (2007) Cellular functions of PDE4 enzymes. D. ), Cyclic Nucleotide Phosphodiesterases in Health and Disease, Boca Raton, FL: CRC Press, pp.
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2006) Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc. Natl. Acad. Sci. USA, 103:15124–15129. 118. , and De Vente, J. (2003) mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain. J. Comp. , 467:566–580. 34 PHOSPHODIESTERASES AND CYCLIC NUCLEOTIDE SIGNALING IN THE CNS 119. , and de Vente, J. (2004) Species differences in the localization of cGMP-producing and NOresponsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry.
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