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In Chapter 5, we discuss the biochemical characteristics of several DNA binding proteins, one of which is the so-called "zinc-finger" domain of the glucocorticoid receptor shown on the cover. Chapters 1120 describe cellular control of key metabolic processes, and one example is the role the glucocorticoid receptor plays in modulating glucose production by the liver. Finally in chapter 29, we show how the glucocorticoid receptor is activated by hormone binding to function as a eukaryotic transcription factor capable of altering the expression of specific genes.

Within the nucleoplasm are found: 1. The nuclear lamina beneath the nuclear membrane 2. The nuclear matrix organizing the chromosomes within the nucleus 3. The nucleolus where ribosomal RNA molecules are made (Chapter 24) The nucleus is both the site of almost all nucleic acid synthesis in the cell (Chapter 24) and the location of most of the hereditary material of the cell. In the molecular biology section of this book (chapters 2131, we will see how the nucleus plays a critical role in separating transcription (RNA synthesis) from translation (protein synthesis).

Despite the common notion that a teacher's job is to stuff things inknowledge, manners, behaviorsmost great educators agree that "leading out" is the true task, helping students develop an appetite for knowledge and an appreciation for its fruits, and guiding them to where and how it can be found. Education is empowerment. Identification of key concepts and rejection of extraneous material were critical tasks in preparing this text. In our teaching, we have made decisions, sometime heart-wrenching, to omit details and topics that may have been critical to our own understanding or are just too elegant or fascinating for most authors to omit.

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