Download Bipolar Depression: Molecular Neurobiology, Clinical by Carlos A. Zarate Jr., Husseini K. Manji PDF

By Carlos A. Zarate Jr., Husseini K. Manji

This e-book brings jointly psychological wellbeing and fitness execs and researchers to provide the main updated details at the prognosis, remedy, and examine surrounding bipolar melancholy. Its person chapters offer useful diagnostic details, permitting clinicians to differentiate among some of the temper issues. extra, they: evaluation the path, end result, and genetics of this hugely heritable ; supply a radical evaluation of the neurobiology of the illness, together with what's identified from neuroimaging paintings; delineate the remedy of bipolar melancholy in specified populations resembling kids and pregnant ladies; deal with suicide, concentrating on the necessity for overview in the course of either acute and upkeep remedy with interventions applicable to a patient’s indicators and background; and canopy acute and long term remedy concepts for bipolar melancholy, together with either conventional and novel therapeutics for the affliction, in addition to non-pharmacological treatments.

This moment variation displays major advances, together with a more robust figuring out of the altered neurobiology of sufferers struggling with bipolar melancholy, new info on pathophysiology and genetic findings drawn from varied reviews, and a dialogue of the numerous strides made in the direction of more advantageous therapy with already on hand and novel agents.

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Additional info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy

Example text

However, no gender differences appear to exist between male and female subjects in time to remission from the index episode, number of recurrences, and time spent with any clinical or subclinical mood symptom over a 48-week period, at least when similar treatment strategies are adopted (Benedetti et al. 2007). 2 Type of Onset and Type of Disorder The length of untreated individual illness episodes in BD varies from several weeks to several months and depends on the type of episode. There are significant differences in time to recovery in patients with BD by episode subtype (Sachs et al.

Escalona and M. Tohen persistence of neurocognitive impairment is associated with poorer psychosocial functioning at any stage. Peripheral biomarkers of inflammation are more likely present at the end stage of BD, consistent with the hypothesis of a neuroprogression of the illness (Kauer-Sant’Anna et al. 2009). However, significant medical and substance abuse comorbidities must be considered as potential confounders. Some neuroimaging findings also suggest some kind of disease progression, but this needs confirmation.

2004). 3 Illness Recurrence and the Course of Syndromal and Functional Recovery Most of the evidence from both the pre-lithium and modern eras suggests that the index episode tends to predict the polarity of the subsequent major mood episode: a manic index episode tends to predict a manic relapse, whereas a depressive index episode predicts a depressive relapse (Calabrese et al. 2004); indexed mixed episodes have been found to predict relapse into a depressive episode (Tohen et al. 2003). The presence of at least two manic/hypomanic symptoms in the index episode is associated with increased family history of BD-I, a higher score for suicidal thoughts during the episode, a longer duration of the episode, and a higher affective morbidity during the observation period (Maj et al.

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