Download Biopsy Interpretation of the Central Nervous System by Matthew J. Schniederjan MD, Daniel J. Brat MD PhD PDF

By Matthew J. Schniederjan MD, Daniel J. Brat MD PhD

It is a sensible advisor and concise reference that may be a significant other textual content for the final surgical pathologist, trainees in pathology and neuropathology, and clinicians who deal with sufferers with neurological ailments that require surgical sampling.

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The histologic diagnosis of CJD requires the presence of gray matter, where the degenerative changes occur. The neuropil contains vacuoles of varying sizes throughout, with a mild reactive gliosis and loss of neurons, but no significant inflammatory infiltrate (Figure 2-22). As the disease progresses, the vacuolations coalesce and impart a ragged appearance on the neuropil. If both white and gray matters are present, the vacuolation should be limited to the latter, or else the suspicion of CJD should be reevaluated.

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2001;71(1):33–9. 78. , Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Br J Haematol. 1995;91(2): 415–8. 79. , Extranodal sinus histiocytosis (Rosai-Dorfman disease) of the brain parenchyma. Acta Neurochir (Wien). 2003;145(2):145–9; discussion 149. 80. , Cerebral localization of Rosai-Dorfman disease in a child. Case report. J Neurosurg. 2007;107(2, Suppl):147–51. 81. , Rosai-Dorfman disease isolated to the central nervous system: a report of 11 cases.

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