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Additional info for Biopsy Interpretation of the Central Nervous System
The histologic diagnosis of CJD requires the presence of gray matter, where the degenerative changes occur. The neuropil contains vacuoles of varying sizes throughout, with a mild reactive gliosis and loss of neurons, but no significant inflammatory infiltrate (Figure 2-22). As the disease progresses, the vacuolations coalesce and impart a ragged appearance on the neuropil. If both white and gray matters are present, the vacuolation should be limited to the latter, or else the suspicion of CJD should be reevaluated.
2007;107(2, Suppl):147–51. 81. , Rosai-Dorfman disease isolated to the central nervous system: a report of 11 cases. Mod Pathol. 2001;14(3):172–8. 82. , Rosai-Dorfman disease isolated to the central nervous system: a report of six cases. Neuropathology. 2010;30(2):154–8. 83. , Inflammatory meningeal masses of unexplained origin. An ultrastructural and immunological study. J Neuropathol Exp Neurol. 1983;42(4):453–68. 84. , The diagnostic difficulties of meningeal and intracerebral plasma cell granulomas—presentation of three cases.
2001;71(1):33–9. 78. , Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Br J Haematol. 1995;91(2): 415–8. 79. , Extranodal sinus histiocytosis (Rosai-Dorfman disease) of the brain parenchyma. Acta Neurochir (Wien). 2003;145(2):145–9; discussion 149. 80. , Cerebral localization of Rosai-Dorfman disease in a child. Case report. J Neurosurg. 2007;107(2, Suppl):147–51. 81. , Rosai-Dorfman disease isolated to the central nervous system: a report of 11 cases.
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