By Stefan Hohmann
Aquaporins summarizes the current wisdom during this increasing box of analysis, beginning with the structural research of water channel proteins. next chapters start with mammalian aquaporins, studying body structure and pathophysiology, research of knock-out version animals, and the rules of aquaporin functionality. additionally lined is the distribution and legislation of aquaporins in crops and the functionality of water and glycerol channels in microbial structures. Key good points* entire therapy of a topical examine box* Authored by way of global leaders within the box* Covers structural biology and body structure* Covers varied experimental and organic platforms* Chapters on plant and microbial platforms* vast therapy of mammalian body structure and pathophysiology* Structural research excellently illustrated
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Additional info for Aquaporins
14). This provides an interesting lesson on the need for care during phenotype determinations, because the plants appeared similar above the surface. Curiously, another aquaporin homolog TobRB7 is up-regulated FIGURE 14 Functional consequence of aquaporin PIP1b expression in A. thaliana. (Left) Plant overexpressing antisense RNA exhibits low PIP1b protein content and compensates with increased arborization of rootlets. (Right) Genetically unmodiﬁed plant. , 1998). 1. , 1994). To preserve the wellrecognized beneﬁts of genetic diversity (hybrid vigor), most plants defend against self-pollination.
Molecular design of aquaporin-1 water channel as revealed by electron crystallography. Nature Struct. Biol. 4, 263–265. , Lee, M. , Smith, B. , Jung, J. , Verdijk, M. A. , Rijss, J. P. , and Deen, P. (1996). The human aquaporin-4 gene: Deﬁnition of the locus encoding two water channel polypeptides in brain. Proc. Natl. Acad. Sci. USA 93, 10908–10912. 1. , and Verkman, A. S. (1994). Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter.
Cell Biol. 120, 371– 383. , Smith, B. , Christensen, E. , and Agre, P. (1993b). Distribution of aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sci. USA 90, 7275–7279. , Chou, C. , Christensen, E. , Kishore, B. , and Knepper, M. A. (1995a). Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc. Natl. Acad. Sci. USA 92, 1013–1017. , Smith, B. , Christensen, E.
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